Small molecule grp94 inhibitors with antiviral activity against Dengue and Zika virus

Two major flaviviruses, dengue virus (DENV) and Zika virus (ZIKV), cause severe health and economic burdens worldwide. Recently, genome-wide screenings have uncovered the importance of the Hrd1 ubiquitin ligase-mediated endoplasmic reticulum (ER)-associated degradation (ERAD) pathway for flavivirus...

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Detalhes bibliográficos
Publicado no:Antiviral Res
Main Authors: Rothan, Hussin A., Zhong, Yongwang, Sanborn, Mark A., Teoh, Teow Chong, Ruan, Jingjing, Yusof, Rohana, Hang, Jun, Henderson, Mark J., Fang, Shengyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801034/
https://ncbi.nlm.nih.gov/pubmed/31421166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2019.104590
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