Integrated target-based and phenotypic screening approaches for the identification of anti-tubercular agents that bind to the mycobacterial adenylating enzyme MbtA

Iron is essential for the pathogenicity and virulence of Mycobacterium tuberculosis, which synthesises salicyl-capped siderophores (mycobactins) to acquire this element from the host. MbtA is the adenylating enzyme that catalyses the initial reaction of mycobactins’ biosynthesis and is solely expres...

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Pubblicato in:ChemMedChem
Autori principali: Ferguson, Lindsay, Wells, Geoff, Bhakta, Sanjib, Johnson, James, Guzman, Junitta, Parish, Tanya, Prentice, Robin A., Brucoli, Federico
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800809/
https://ncbi.nlm.nih.gov/pubmed/31454170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900217
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