Analysis of RNA methylation by phylogenetically diverse Cfr radical SAM enzymes reveals an iron-binding accessory domain in a clostridial enzyme

Cfr is a radical S-adenosylmethionine (SAM) RNA methylase linked to multi-drug antibiotic resistance in bacterial pathogens. It catalyzes a chemically challenging C-C-bond forming reaction to methylate C8 of A2503 [Escherichia coli (Ec) numbering) of 23S ribosomal RNA during ribosome assembly. The c...

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Publicado en:Biochemistry
Main Authors: Gumkowski, James D., Martinie, Ryan J., Corrigan, Patrick S., Pan, Juan, Bauerle, Matthew R., Almarei, Mohamed, Booker, Squire J., Silakov, Alexey, Krebs, Carsten, Boal, Amie K.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800567/
https://ncbi.nlm.nih.gov/pubmed/31246421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00197
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