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Analysis of RNA methylation by phylogenetically diverse Cfr radical SAM enzymes reveals an iron-binding accessory domain in a clostridial enzyme
Cfr is a radical S-adenosylmethionine (SAM) RNA methylase linked to multi-drug antibiotic resistance in bacterial pathogens. It catalyzes a chemically challenging C-C-bond forming reaction to methylate C8 of A2503 [Escherichia coli (Ec) numbering) of 23S ribosomal RNA during ribosome assembly. The c...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800567/ https://ncbi.nlm.nih.gov/pubmed/31246421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00197 |
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