Sialic acid mediated mechanical activation of β(2) adrenergic receptors by bacterial pili

Meningococcus utilizes β-arrestin selective activation of endothelial cell β(2) adrenergic receptor (β(2)AR) to cause meningitis in humans. Molecular mechanisms of receptor activation by the pathogen and of its species selectivity remained elusive. We report that β(2)AR activation requires two aspar...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Virion, Zoe, Doly, Stéphane, Saha, Kusumika, Lambert, Mireille, Guillonneau, François, Bied, Camille, Duke, Rebecca M., Rudd, Pauline M., Robbe-Masselot, Catherine, Nassif, Xavier, Coureuil, Mathieu, Marullo, Stefano
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800425/
https://ncbi.nlm.nih.gov/pubmed/31628314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12685-6
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