Sialic acid mediated mechanical activation of β(2) adrenergic receptors by bacterial pili

Meningococcus utilizes β-arrestin selective activation of endothelial cell β(2) adrenergic receptor (β(2)AR) to cause meningitis in humans. Molecular mechanisms of receptor activation by the pathogen and of its species selectivity remained elusive. We report that β(2)AR activation requires two aspar...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Virion, Zoe, Doly, Stéphane, Saha, Kusumika, Lambert, Mireille, Guillonneau, François, Bied, Camille, Duke, Rebecca M., Rudd, Pauline M., Robbe-Masselot, Catherine, Nassif, Xavier, Coureuil, Mathieu, Marullo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800425/
https://ncbi.nlm.nih.gov/pubmed/31628314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12685-6
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