Sialic acid mediated mechanical activation of β(2) adrenergic receptors by bacterial pili

Meningococcus utilizes β-arrestin selective activation of endothelial cell β(2) adrenergic receptor (β(2)AR) to cause meningitis in humans. Molecular mechanisms of receptor activation by the pathogen and of its species selectivity remained elusive. We report that β(2)AR activation requires two aspar...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Virion, Zoe, Doly, Stéphane, Saha, Kusumika, Lambert, Mireille, Guillonneau, François, Bied, Camille, Duke, Rebecca M., Rudd, Pauline M., Robbe-Masselot, Catherine, Nassif, Xavier, Coureuil, Mathieu, Marullo, Stefano
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800425/
https://ncbi.nlm.nih.gov/pubmed/31628314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12685-6
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