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Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry

Short linear peptide motifs that are intracellular ligands of folded proteins are a modular, incompletely understood molecular interaction language in signaling systems. Such motifs, which frequently occur in intrinsically disordered protein regions, often bind partner proteins with modest affinity...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Parker, Benjamin W., Goncz, Edward J., Krist, David T., Statsyuk, Alexander V., Nesvizhskii, Alexey I., Weiss, Eric L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800362/
https://ncbi.nlm.nih.gov/pubmed/31578253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819533116
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