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Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation
Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with human and murine B7.1 (CD80) and B7.2 (CD86). We a...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800355/ https://ncbi.nlm.nih.gov/pubmed/31575740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909414116 |
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