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Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation
Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with human and murine B7.1 (CD80) and B7.2 (CD86). We a...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800355/ https://ncbi.nlm.nih.gov/pubmed/31575740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909414116 |
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