Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation

Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with human and murine B7.1 (CD80) and B7.2 (CD86). We a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Xiaoli, Piersma, Sytse J., Elliott, Jabari I., Errico, John M., Gainey, Maria D., Yang, Liping, Nelson, Christopher A., Yokoyama, Wayne M., Fremont, Daved H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800355/
https://ncbi.nlm.nih.gov/pubmed/31575740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909414116
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