Amyloid-beta impairs TOM1-mediated IL-1R1 signaling

Defects in interleukin-1β (IL-1β)–mediated cellular responses contribute to Alzheimer’s disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the termination of IL-1β inflammatory responses by focusing on the role played by the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cadete Martini, Alessandra, Gomez-Arboledas, Angela, Forner, Stefania, Rodriguez-Ortiz, Carlos J., McQuade, Amanda, Danhash, Emma, Phan, Jimmy, Javonillo, Dominic, Ha, Jordan-Vu, Tram, Melanie, Trujillo-Estrada, Laura, da Cunha, Celia, Ager, Rahasson R., Davila, Jose C., Kitazawa, Masashi, Blurton-Jones, Mathew, Gutierrez, Antonia, Baglietto-Vargas, David, Medeiros, Rodrigo, LaFerla, Frank M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800331/
https://ncbi.nlm.nih.gov/pubmed/31570577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914088116
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