Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation

Charge selectivity forms the basis of cellular excitation or inhibition by Cys-loop ligand-gated ion channels (LGICs), and is essential for physiological receptor function. There are no reports of naturally occurring mutations in LGICs associated with the conversion of charge selectivity. Here, we r...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cetin, Hakan, Epstein, Max, Liu, Wei W., Maxwell, Susan, Rodriguez Cruz, Pedro M., Cossins, Judith, Vincent, Angela, Webster, Richard, Biggin, Philip C., Beeson, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800317/
https://ncbi.nlm.nih.gov/pubmed/31570625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908284116
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