Ccnel Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

BACKGROUND & AIMS: The CCNE1 locus, which encodes cyclin E1, is amplified in many types of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the virus nearby. We investigated cel...

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Pubblicato in:Gastroenterology
Autori principali: Aziz, Khaled, Limzerwala, Jazeel F., Sturmlechner, Ines, Hurley, Erin, Zhang, Cheng, Jeganathan, Karthik B., Nelson, Grace, Bronk, Steve, Velasco, Raul Fierro, van Deursen, Erik-Jan, O’Brien, Daniel R., Kocher, Jean-Pierre A., Youssef, Sameh A., van Ree, Janine H., de Bruin, Alain, van den Bos, Hilda, Spierings, Diana C.J., Foijer, Floris, van de Sluis, Bart, Roberts, Lewis R., Gores, Gregory, Li, Hu, van Deursen, Jan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800187/
https://ncbi.nlm.nih.gov/pubmed/30878468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.03.016
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