TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice

INTRODUCTION: Administration of cholic acid, or its synthetic derivative, 6-alpha-ethyl-23(S)-methylcholic acid (INT-777), activates the membrane GPCR, TGR5, influences whole body metabolism, reduces atherosclerosis, and benefits the cardiovascular physiology in mice. Direct effects of TGR5 agonists...

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Vydáno v:Cardiovasc Ther
Hlavní autoři: Eblimit, Zeena, Thevananther, Sundararajah, Karpen, Saul J., Taegtmeyer, Heinrich, Moore, David D., Adorini, Luciano, Penny, Daniel J., Desai, Moreshwar S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800140/
https://ncbi.nlm.nih.gov/pubmed/30070769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1755-5922.12462
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