Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart

Cardiac dysfunction in patients with liver cirrhosis is strongly associated with increased serum bile acid concentrations. Here we show that excess bile acids decrease fatty acid oxidation in cardiomyocytes and can cause heart dysfunction, a cardiac syndrome that we term Cholecardia. Fxr; Shp double...

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Vydáno v:Hepatology
Hlavní autoři: Desai, Moreshwar, Mathur, Bhoomika, Eblimit, Zeena, Vasquez, Hernan, Taegtmeyer, Heinrich, Karpen, Saul, Penny, Daniel J., Moore, David D., Anakk, Sayeepriyadarshini
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299964/
https://ncbi.nlm.nih.gov/pubmed/27774647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28890
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