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Impaired bile acid handling and aggravated liver injury in mice expressing a hepatocyte-specific RXRα variant lacking the DNA-Binding Domain

BACKGROUND/AIMS: Retinoid X Receptor α (RXRα) is the principal heterodimerization partner of class II Nuclear Receptors (NRs), and a major regulator of gene expression of numerous hepatic processes, including bile acid (BA) homeostasis through multiple partners. Specific contributions of hepatic RXR...

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Detalhes bibliográficos
Main Authors: Kosters, Astrid, Felix, Julio C., Desai, Moreshwar S., Karpen, Saul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946967/
https://ncbi.nlm.nih.gov/pubmed/24120911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.09.026
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