Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

Data from mouse tumor models suggest that tumor-associated monocyte/macrophage lineage cells (MMLCs) dampen antitumor immune responses. However, given the fundamental differences between mice and humans in tumor evolution, genetic heterogeneity, and immunity, the function of MMLCs might be different...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Singhal, Sunil, Stadanlick, Jason, Annunziata, Michael J., Rao, Abhishek S., Bhojnagarwala, Pratik S., O’Brien, Shaun, Moon, Edmund K., Cantu, Edward, Danet-Desnoyers, Gwenn, Ra, Hyun-Jeong, Litzky, Leslie, Akimova, Tatiana, Beier, Ulf H., Hancock, Wayne W., Albelda, Steven M., Eruslanov, Evgeniy B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800123/
https://ncbi.nlm.nih.gov/pubmed/30760579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat1500
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