Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms

We report that human conventional CD15(+) neutrophils can be isolated in the peripheral blood mononuclear cell (PBMC) layer during Ficoll gradient separation, and that they can impair T cell proliferation in vitro without concomitant neutrophil activation and killing. This effect was observed in a t...

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Publicado en:Sci Rep
Main Authors: Negorev, Dmitri, Beier, Ulf H., Zhang, Tianyi, Quatromoni, Jon G., Bhojnagarwala, Pratik, Albelda, Steven M., Singhal, Sunil, Eruslanov, Evgeniy, Lohoff, Falk W., Levine, Matthew H., Diamond, Joshua M., Christie, Jason D., Hancock, Wayne W., Akimova, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816646/
https://ncbi.nlm.nih.gov/pubmed/29453429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21450-6
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