The timing of TGF-β inhibition affects the generation of antigen-specific CD8(+) T Cells

BACKGROUND: Transforming growth factor (TGF)-β is a potent immunosuppressive cytokine necessary for cancer growth. Animal and human studies have shown that pharmacologic inhibition of TGF-β slows the growth rate of established tumors and occasionally eradicates them altogether. We observed, paradoxi...

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Detalhes bibliográficos
Main Authors: Quatromoni, Jon G, Suzuki, Eiji, Okusanya, Olugbenga, Judy, Brendan F, Bhojnagarwala, Pratik, Venegas, Ollin, Eruslanov, Evgeniy, Predina, Jarrod D, Albelda, Steven M, Singhal, Sunil
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725164/
https://ncbi.nlm.nih.gov/pubmed/23865808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-14-30
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