Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma

PURPOSE: Glioblastoma (GBM) is the most common primary central nervous system cancer in adults. Oncolytic HSV-1 (oHSV) is the first FDA-approved gene therapy approach for the treatment of malignant melanoma. For GBM, oHSVs need to be engineered to replicate within and be toxic to the glial tumor but...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Nakashima, Hiroshi, Nguyen, Tran, Kasai, Kazue, Passaro, Carmela, Ito, Hirotaka, Goins, William F., Shaikh, Imran, Erdelyi, Ronald, Nishihara, Reiko, Nakano, Ichiro, Reardon, David A., Anderson, Ana C., Kuchroo, Vijay, Chiocca, E. Antonio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800093/
https://ncbi.nlm.nih.gov/pubmed/29511029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2954
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