2097: Aging-associated increases in platelet granzyme A regulate pro-inflammatory gene synthesis by monocytes

OBJECTIVES/SPECIFIC AIMS: Platelets govern signal-dependent inflammatory responses by leukocytes. Although dysregulated inflammation is common in older adults, platelet-leukocyte signaling events and downstream inflammatory gene synthesis in aging is not known. METHODS/STUDY POPULATION: Highly-purif...

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Detalhes bibliográficos
Publicado no:J Clin Transl Sci
Main Authors: Thomas Rondina, Matthew, Campbell, Robert A., Bhatnagar, Anish, Franks, Zechariah, Rowley, Jesse W., Kanth Manne, Bhanu, Supiano, Mark A., Ward, Alistair N.
Formato: Artigo
Idioma:Inglês
Publicado em: Cambridge University Press 2018
Assuntos:
Mechanistic Basic to Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799727/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2017.201
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