2559 Role of tissue non-specific alkaline phosphatase (TNAP) in promoting the survival of acute myeloid leukemia (AML) cells within the bone marrow microenvironment

OBJECTIVES/SPECIFIC AIMS: Treatment of acute myeloid leukemia (AML) is challenging, as apoptosis-resistant AML cells often persist within the bone marrow microenvironment despite chemotherapy. The overall goal of our laboratory is to identify and ultimately target the bone marrow factors that protec...

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Pubblicato in:J Clin Transl Sci
Autori principali: Bowles, Bradley, Sterner, Rosalie M., Kremer, Kimberly N., Dudakovic, Amel, Westendorf, Jennifer J., Van Wijnen, Andre J., Hedin, Karen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cambridge University Press 2018
Soggetti:
Basic/Translational Science/Team Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799340/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2018.119
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