3488 A comparison between the Rolling 6 and 3+3 dose escalation study designs for phase 1 clinical trials

OBJECTIVES/SPECIFIC AIMS: The development of new anti-cancer agents for children requires an inherently longer timeline than in adults. The 3+3 study design for Phase 1 dose escalation trials is commonly used to estimate the maximum tolerated dose and assess safety. The Rolling 6 study design was de...

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Pubblicato in:J Clin Transl Sci
Autori principali: Minard, Charles Gene, Rau, Rachel, Hilsenbeck, Susan, Weigel, Brenda J., Fox, Elizabeth, Adamson, Peter, Blaney, Susan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cambridge University Press 2019
Soggetti:
Clinical Epidemiology/Clinical Trial
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799314/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.73
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