3158 Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model

OBJECTIVES/SPECIFIC AIMS: The aims of this study are threefold. Firstly, we are examining the effects of increased in vitro afterload (a proxy for hypertension) on human induced pluripotent stem cell cardiomyocyte (hiPSC-CM) response to sunitinib in a durable and dynamic cardiac microtissue culture...

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Dettagli Bibliografici
Pubblicato in:J Clin Transl Sci
Autori principali: Livingston, Carissa, Ramachandran, Abhinay, Corbin, Elise, Vite, Alexia, Bennett, Alexander, Margulies, Kenneth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cambridge University Press 2019
Soggetti:
Mechanistic Basic to Clinical
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799294/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.262
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