2193: Targeting MELK in acute lymphoblastic leukemia, new therapeutic approach

OBJECTIVES/SPECIFIC AIMS: Unlike the high cure rates (90%) of children with acute lymphoblastic leukemia (ALL), that of adults is still lagging behind and better therapies are needed. Maternal embryonic leucine-zipper kinase (MELK) is aberrantly upregulated in cancer, and implicated in cancer stem c...

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Udgivet i:J Clin Transl Sci
Main Authors: Alachkar, Houda, Mutonga, Martin, de Albuquerque, Amanda, Deo, Rucha, Malnassy, Gregory, Nakamura, Yusuke, Stock, Wendy
Format: Artigo
Sprog:Inglês
Udgivet: Cambridge University Press 2018
Fag:
Mechanistic Basic to Clinical
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799002/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2017.209
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