Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia

Asparaginase, which depletes asparagine and glutamine, activates amino acid stress response. Oxidative stress mediated by excessive reactive oxygen species (ROS) causes enhanced mitochondrial permeabilization and subsequent cell apoptosis and is considered a plausible mechanism for drug-induced hepa...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Pharmacogenomics J
Autors principals: Alachkar, Houda, Fulton, Noreen, Sanford, Ben, Malnassy, Greg, Mutonga, Martin, Larson, Richard A., Bloomfield, Clara D., Marcucci, Guido, Nakamura, Yusuke, Stock, Wendy
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089920/
https://ncbi.nlm.nih.gov/pubmed/27019981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2016.7
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars