Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia

Maternal embryonic leucine-zipper kinase (MELK), which was reported to be frequently up-regulated in various types of solid cancer, plays critical roles in formation and maintenance of cancer stem cells. However, little is known about the relevance of this kinase in hematologic malignancies. Here we...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Alachkar, Houda, Mutonga, Martin B.G., Metzeler, Klaus H., Fulton, Noreen, Malnassy, Gregory, Herold, Tobias, Spiekermann, Karsten, Bohlander, Stefan K., Hiddemann, Wolfgang, Matsuo, Yo, Stock, Wendy, Nakamura, Yusuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323011/
https://ncbi.nlm.nih.gov/pubmed/25365263
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