2297 The direct effect of trimethylamine N-oxide (TMAO) on cardiac muscle contractile mechanics

OBJECTIVES/SPECIFIC AIMS: The objective of this study was to determine if trimethylamine N-oxide (TMAO) alone could acutely alter cardiac contractile function on a beat-to-beat basis. METHODS/STUDY POPULATION: CD1 adult mouse hearts were extracted, attached to a force transducer, oxygenated, and pac...

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Bibliographic Details
Published in:J Clin Transl Sci
Main Authors: Oakley, Carlee I., Sanborn, David, Rafie, Nikita, Hendrix, Matt, Grillo, Michael, Vallejo, Julian, Stubbs, Jason R., Shawgo, Tilitha, Daon, Emmanuel, Zorn, George, Wacker, Michael J.
Format: Artigo
Language:Inglês
Published: Cambridge University Press 2018
Subjects:
Basic/Translational Science/Team Science
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798896/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2018.130
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