Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production

Several therapeutic strategies targeting Epstein-Barr virus (EBV)-associated tumors involve upregulation of viral lytic gene expression. Evidence has been presented that the unfolded protein response (UPR) leads to EBV lytic gene expression. Clofoctol, an antibacterial antibiotic, has been reported...

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Bibliographic Details
Published in:J Virol
Main Authors: Lee, Jaeyeun, Kosowicz, John G., Hayward, S. Diane, Desai, Prashant, Stone, Jennifer, Lee, Jae Myun, Liu, Jun O., Ambinder, Richard F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798122/
https://ncbi.nlm.nih.gov/pubmed/31341058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00998-19
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