Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production

Several therapeutic strategies targeting Epstein-Barr virus (EBV)-associated tumors involve upregulation of viral lytic gene expression. Evidence has been presented that the unfolded protein response (UPR) leads to EBV lytic gene expression. Clofoctol, an antibacterial antibiotic, has been reported...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Lee, Jaeyeun, Kosowicz, John G., Hayward, S. Diane, Desai, Prashant, Stone, Jennifer, Lee, Jae Myun, Liu, Jun O., Ambinder, Richard F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6798122/
https://ncbi.nlm.nih.gov/pubmed/31341058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00998-19
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