Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation

Epstein-Barr virus (EBV) is a ubiquitous human gammaherpesvirus that establishes a latency reservoir in B cells. In this work, we show that ibrutinib, idelalisib, and dasatinib, drugs that block B cell receptor (BCR) signaling and are used in the treatment of hematologic malignancies, block BCR-medi...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kosowicz, John G., Lee, Jaeyeun, Peiffer, Brandon, Guo, Zufeng, Chen, Jianmeng, Liao, Gangling, Hayward, S. Diane, Liu, Jun O., Ambinder, Richard F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533897/
https://ncbi.nlm.nih.gov/pubmed/28566383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00747-17
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