Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis

Mutations in SPG11, leading to loss of spatacsin function, impair the formation of membrane tubules in lysosomes and cause lysosomal lipid accumulation. However, the full nature of lipids accumulating in lysosomes and the physiological consequences of such accumulation are unknown. Here we show that...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Boutry, Maxime, Pierga, Alexandre, Matusiak, Raphaël, Branchu, Julien, Houllegatte, Marc, Ibrahim, Yoan, Balse, Elise, El Hachimi, Khalid-Hamid, Brice, Alexis, Stevanin, Giovanni, Darios, Frédéric
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797781/
https://ncbi.nlm.nih.gov/pubmed/31637311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0615-z
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