Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis

Mutations in SPG11, leading to loss of spatacsin function, impair the formation of membrane tubules in lysosomes and cause lysosomal lipid accumulation. However, the full nature of lipids accumulating in lysosomes and the physiological consequences of such accumulation are unknown. Here we show that...

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Detalles Bibliográficos
Publicado en:Commun Biol
Main Authors: Boutry, Maxime, Pierga, Alexandre, Matusiak, Raphaël, Branchu, Julien, Houllegatte, Marc, Ibrahim, Yoan, Balse, Elise, El Hachimi, Khalid-Hamid, Brice, Alexis, Stevanin, Giovanni, Darios, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797781/
https://ncbi.nlm.nih.gov/pubmed/31637311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0615-z
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