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Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics
The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in animal models of pain. Here, we have used functio...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6797481/ https://ncbi.nlm.nih.gov/pubmed/31621581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47150 |
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