Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in animal models of pain. Here, we have used functio...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Mostyn, Shannon N, Wilson, Katie A, Schumann-Gillett, Alexandra, Frangos, Zachary J, Shimmon, Susan, Rawling, Tristan, Ryan, Renae M, O'Mara, Megan L, Vandenberg, Robert J
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797481/
https://ncbi.nlm.nih.gov/pubmed/31621581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47150
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