Topoisomerase IB poisons induce histone H2A phosphorylation as a response to DNA damage in Leishmania infantum

DNA topoisomerases are considered consolidated druggable targets against diseases produced by trypanosomatids. Several reports indicated that indenoisoquinolines, a family of non-camptothecinic based topoisomerase poisons, have a strong leishmanicidal effect both in vitro and in vivo in murine model...

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Udgivet i:Int J Parasitol Drugs Drug Resist
Main Authors: Gutiérrez-Corbo, Camino, Álvarez-Velilla, Raquel, Reguera, Rosa M., García-Estrada, Carlos, Cushman, Mark, Balaña-Fouce, Rafael, Pérez-Pertejo, Yolanda
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796659/
https://ncbi.nlm.nih.gov/pubmed/31563118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2019.09.005
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