Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer

BACKGROUND: Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and di...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Yu, Yu, Suryo Rahmanto, Yohan, Shen, Yao-An, Ardighieri, Laura, Davidson, Ben, Gaillard, Stephanie, Ayhan, Ayse, Shi, Xu, Xuan, Jianhua, Wang, Tian-Li, Shih, Ie-Ming
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Research paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796592/
https://ncbi.nlm.nih.gov/pubmed/31492560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.08.055
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