Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer

BACKGROUND: Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and di...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EBioMedicine
Prif Awduron: Yu, Yu, Suryo Rahmanto, Yohan, Shen, Yao-An, Ardighieri, Laura, Davidson, Ben, Gaillard, Stephanie, Ayhan, Ayse, Shi, Xu, Xuan, Jianhua, Wang, Tian-Li, Shih, Ie-Ming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Research paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796592/
https://ncbi.nlm.nih.gov/pubmed/31492560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.08.055
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