Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules

Resistance to chemotherapy represents a major obstacle for long-term remission and effective strategies to overcome drug resistance would have significant clinical impact. We report here that after paclitaxel/carboplatin treatment, ovarian carcinomas have upregulated spleen tyrosine kinase (SYK) and...

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Pubblicato in:Cancer Cell
Autori principali: Yu, Yu, Gaillard, Stephanie, Phillip, Jude M., Huang, Tai-Chung, Pinto, Sneha M, Tessarollo, Nayara G., Zhang, Zhen, Pandey, Akhilesh, Wirtz, Denis, Ayhan, Ayse, Davidson, Ben, Wang, Tian-Li, Shih, Ie-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257279/
https://ncbi.nlm.nih.gov/pubmed/26096845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.05.009
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