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Effect of c-Abl tyrosine kinase on the cellular response to paclitaxel-induced microtubule damage
DNA damage has been shown to activate c-Abl tyrosine kinase. We now report that, in addition to DNA damage, microtubule damage induced by paclitaxel results in activation of c-Abl kinase. In 3T3 cells, the presence of c-Abl kinase increased paclitaxel-induced cell death. In Abl-proficient cells, pac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408779/ https://ncbi.nlm.nih.gov/pubmed/11044362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1440 |
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