P11.45 Synergistic growth inhibition mediated by dual PI3K/mTOR pathway targeting and genetic or direct pharmacological AKT inhibition in human glioblastoma models

BACKGROUND: Molecular genetic aberrations in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway are common in human cancers including glioblastoma, yet, novel therapeutic approaches targeting this pathway in glioblastoma have had limited success...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: von Achenbach, C, Weller, M, Kaulich, K, Gramatzki, D, Zacher, A, Fabbro, D, Reifenberger, G, Szabó, E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Poster Presentations
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796173/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz126.191
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