Celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells

AIM: To investigate the mechanism of celastrol in inhibiting lens epithelial cells (LECs) fibrosis, which is the pathological basis of cataract. METHODS: Human LEC line SRA01/04 was treated with celastrol and transforming growth factor-β2 (TGF-β2). Wound-healing assay, proliferation assay, flow cyto...

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Bibliographic Details
Published in:Int J Ophthalmol
Main Authors: Wang, Li-Ping, Chen, Bao-Xin, Sun, Yan, Chen, Jie-Ping, Huang, Shan, Liu, Yi-Zhi
Format: Artigo
Language:Inglês
Published: International Journal of Ophthalmology Press 2019
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796093/
https://ncbi.nlm.nih.gov/pubmed/31637185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18240/ijo.2019.10.01
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