Celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells

AIM: To investigate the mechanism of celastrol in inhibiting lens epithelial cells (LECs) fibrosis, which is the pathological basis of cataract. METHODS: Human LEC line SRA01/04 was treated with celastrol and transforming growth factor-β2 (TGF-β2). Wound-healing assay, proliferation assay, flow cyt...

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Hauptverfasser: Li-Ping Wang, Bao-Xin Chen, Yan Sun, Jie-Ping Chen, Shan Huang, Yi-Zhi Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Press of International Journal of Ophthalmology (IJO PRESS) 2019-10-01
Schriftenreihe:International Journal of Ophthalmology
Schlagworte:
lens
cataract
fibrosis
transforming growth factor-β2
celastrol
Online Zugang:http://www.ijo.cn/en_publish/2019/10/20191001.pdf
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