Celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells

AIM: To investigate the mechanism of celastrol in inhibiting lens epithelial cells (LECs) fibrosis, which is the pathological basis of cataract. METHODS: Human LEC line SRA01/04 was treated with celastrol and transforming growth factor-β2 (TGF-β2). Wound-healing assay, proliferation assay, flow cyto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Ophthalmol
Prif Awduron: Wang, Li-Ping, Chen, Bao-Xin, Sun, Yan, Chen, Jie-Ping, Huang, Shan, Liu, Yi-Zhi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: International Journal of Ophthalmology Press 2019
Pynciau:
Basic Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796093/
https://ncbi.nlm.nih.gov/pubmed/31637185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18240/ijo.2019.10.01
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