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Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation

Gene transcription in animals involves the assembly of RNA polymerase II at core promoters and its cell type-specific activation by enhancers that can be located more distally(1). However, how ubiquitous expression of housekeeping genes is achieved has remained less clear. In particular, it is unkno...

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Podrobná bibliografie
Vydáno v:Nature
Hlavní autoři: Zabidi, Muhammad A., Arnold, Cosmas D., Schernhuber, Katharina, Pagani, Michaela, Rath, Martina, Frank, Olga, Stark, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795551/
https://ncbi.nlm.nih.gov/pubmed/25517091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13994
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