HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia

Osteolytic bone lesions and hypercalcemia are common, serious complications in adult T cell leukemia/lymphoma (ATL), an aggressive T cell malignancy associated with human T cell leukemia virus type 1 (HTLV-1) infection. The HTLV-1 viral oncogene HBZ has been implicated in ATL tumorigenesis and bone...

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Publicat a:JCI Insight
Autors principals: Xiang, Jingyu, Rauch, Daniel A., Huey, Devra D., Panfil, Amanda R., Cheng, Xiaogang, Esser, Alison K., Su, Xinming, Harding, John C., Xu, Yalin, Fox, Gregory C., Fontana, Francesca, Kobayashi, Takayuki, Su, Junyi, Sundaramoorthi, Hemalatha, Wong, Wing Hing, Jia, Yizhen, Rosol, Thomas J., Veis, Deborah J., Green, Patrick L., Niewiesk, Stefan, Ratner, Lee, Weilbaecher, Katherine N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795409/
https://ncbi.nlm.nih.gov/pubmed/31578308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128713
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