HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia

Osteolytic bone lesions and hypercalcemia are common, serious complications in adult T cell leukemia/lymphoma (ATL), an aggressive T cell malignancy associated with human T cell leukemia virus type 1 (HTLV-1) infection. The HTLV-1 viral oncogene HBZ has been implicated in ATL tumorigenesis and bone...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Xiang, Jingyu, Rauch, Daniel A., Huey, Devra D., Panfil, Amanda R., Cheng, Xiaogang, Esser, Alison K., Su, Xinming, Harding, John C., Xu, Yalin, Fox, Gregory C., Fontana, Francesca, Kobayashi, Takayuki, Su, Junyi, Sundaramoorthi, Hemalatha, Wong, Wing Hing, Jia, Yizhen, Rosol, Thomas J., Veis, Deborah J., Green, Patrick L., Niewiesk, Stefan, Ratner, Lee, Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795409/
https://ncbi.nlm.nih.gov/pubmed/31578308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128713
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