Comparison of Five Peptide Vectors for Improved Brain Delivery of the Lysosomal Enzyme Arylsulfatase A

Enzyme replacement therapy (ERT) is a treatment option for lysosomal storage disorders (LSDs) caused by deficiencies of soluble lysosomal enzymes. ERT depends on receptor-mediated transport of intravenously injected recombinant enzyme to lysosomes of patient cells. The blood–brain barrier (BBB) prev...

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Publicado en:J Neurosci
Main Authors: Böckenhoff, Annika, Cramer, Sandra, Wölte, Philipp, Knieling, Simeon, Wohlenberg, Claudia, Gieselmann, Volkmar, Galla, Hans-Joachim, Matzner, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795304/
https://ncbi.nlm.nih.gov/pubmed/24573272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4785-13.2014
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