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Saposin B-dependent Reconstitution of Arylsulfatase A Activity in Vitro and in Cell Culture Models of Metachromatic Leukodystrophy

Arylsulfatase A (ASA) catalyzes the intralysosomal desulfation of 3-O-sulfogalactosylceramide (sulfatide) to galactosylceramide. The reaction requires saposin B (Sap B), a non-enzymatic proteinaceous cofactor which presents sulfatide to the catalytic site of ASA. The lack of either ASA or Sap B resu...

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Detaylı Bibliyografya
Asıl Yazarlar: Matzner, Ulrich, Breiden, Bernadette, Schwarzmann, Günter, Yaghootfam, Afshin, Fluharty, Arvan L., Hasilik, Andrej, Sandhoff, Konrad, Gieselmann, Volkmar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666589/
https://ncbi.nlm.nih.gov/pubmed/19224915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809457200
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