Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain

Insulin resistance associates with increased risk for cognitive decline and dementia; however, the underpinning mechanisms for this increased risk remain to be fully defined. As insulin resistance impairs mitochondrial oxidative metabolism and increases ROS in skeletal muscle, we considered whether...

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Udgivet i:JCI Insight
Main Authors: Ruegsegger, Gregory N., Vanderboom, Patrick M., Dasari, Surendra, Klaus, Katherine A., Kabiraj, Parijat, McCarthy, Christina B., Lucchinetti, Claudia F., Nair, K. Sreekumaran
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795285/
https://ncbi.nlm.nih.gov/pubmed/31534057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130681
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