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A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia
TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. We hypothesized that TIGAR plays a neuroprotective role in brain ischemia as neurons do not rely on glycolysis but are vulnerable...
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| Publicado en: | J Neurosci |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6795245/ https://ncbi.nlm.nih.gov/pubmed/24872551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4655-13.2014 |
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