A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. We hypothesized that TIGAR plays a neuroprotective role in brain ischemia as neurons do not rely on glycolysis but are vulnerable...

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Vydáno v:J Neurosci
Hlavní autoři: Li, Mei, Sun, Meiling, Cao, Lijuan, Gu, Jin-hua, Ge, Jianbin, Chen, Jieyu, Han, Rong, Qin, Yuan-Yuan, Zhou, Zhi-Peng, Ding, Yuqiang, Qin, Zheng-Hong
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795245/
https://ncbi.nlm.nih.gov/pubmed/24872551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4655-13.2014
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